Modification of PET surfaces with gum Arabic towards its bacterial anti-adhesiveness using an experimental factorial design approach

Bacterial adhesion onto hospital material surfaces still represents a big healthcare issue, being preventive measures required to mitigate this problem, such as increasing surface hydrophilicity. In the present study, gum Arabic, hydrophilic polysaccharide, was used modify of polyethylene terephthalate (PET). Initial water contact angle (WCA) and WCA after several washing cycles were studied response variables by 24 full factorial design. Several reaction parameters, time between Arabic PET, concentration, curing temperature for PET modification investigated. The most significant parameters found be time. optimized led reduction from 70° 27°. modified samples characterized using techniques including AFM, colorimetric, ATR-FTIR which further confirmed successful modification. Furthermore, bacterial assays have clearly shown that treated highly effective in preventing Escherichia coli expressing YadA, an adhesive protein Yersinia so-called adhesin. use design experiments allowed successfully attaining with high anti-adhesiveness, simple grafting approach.